the effect of opium dependency of parent (s) on offspring’s spatial learning & memory in adult male rats

نویسندگان

arezoo saberi moghadam kerman neuroscience research center, kerman university of medical sciences kerman, iran

gholamreza sepehri kerman neuroscience research center, kerman university of medical sciences kerman, iran

vahid sheibani kerman neuroscience research center, kerman university of medical sciences kerman, iran

tahereh haghpanah department of anatomical and reproductive biology, faculty of medical sciences, shahid beheshti university of medical sciences, tehran, iran

چکیده

objective(s):as far as we know,there has been no report regarding the effects of opium addiction or dependency of both parents on the learning and memory process in offspring. the aim of this study was to examine the learning and memory changes of adult male offspring whose mothers, fathers and/or both parents had dependency to opium before and during pregnancy. materials and methods: all experiments were carried out on wistar rats. opium dependency was induced by daily injections of opium (10 mg/kg/sc, bid/10 d) before mating. the presence of a vaginal plug was designated as gestation day. treatment with opium continued through breeding and gestation until parturition. spatial memory was tested in male offspring of control, saline and prenatal opium treated groups by a training trial and the probe test in the morris water maze. swimming escape latency in the maze and the ability to find the platform in the training trial were recorded. the time spent in the trigger zone and number of times the rats crossed the platform during the probe phase and swimming speed were measured. results:thedata revealed increased escape latency and a greater distance traveled to find the hidden platform in the offspring’s whose mother, father and /or both parents were exposed to opium. crossings to target quadrant at probe trials was significantly reduced in all of the prenatal opium exposed offsprings. the swimming speed showed a significant increase in father and parent’s opium exposed offspring.  conclusion:prenatal opium exposure of either parent may cause deficits in spatial learning, but the precise mechanism(s) remain largely unknown.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats

Objective(s):As far as we know,there has been no report regarding the effects of opium addiction or dependency of both parents on the learning and memory process in offspring. The aim of this study was to examine the learning and memory changes of adult male offspring whose mothers, fathers and/or both parents had dependency to opium before and during pregnancy. Materials and Methods: All exper...

متن کامل

The Effect of Opium Dependency of Parent (s) on Offspring’s Spatial Learning & Memory in Adult Male Rats

OBJECTIVE(S) As far as we know, there has been no report regarding the effects of opium addiction or dependency of both parents on the learning and memory process in offspring. The aim of this study was to examine the learning and memory changes of adult male offspring whose mothers, fathers and/or both parents had dependency to opium before and during pregnancy. Materials and Methods : All exp...

متن کامل

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes abstract language learning strategies are of the most important factors that help language learners to learn a foreign language and how they can deal with the four language skills specifically speaking skill effectively. acknowledging the great impact of learning strategies...

The Effect of Intrahippocampal Injection of Ascorbic Asid on Spatial Learning and Memory in Adult Male Rats

Introduction: Ascorbic acid (AA) is present in high concentrations with heterogeneous distribution in the mammalian brain. Previous studies have shown that release of various neurotransmitters such as glutamate, acetylcholine and dopamine might be involved in the central AA release. On the other hand all of these neurotransmitters and the region CA1 of the hippocampus are involved in learnin...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۶، شماره ۵، صفحات ۶۹۴-۶۹۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023